Toxoplasmosis
Findings:
Multiple ring enhancing lesions are present throughout
both cerebral hemispheres, with associated marked edema.
Differential diagnosis:
mets, toxo, lymphoma, TB, abscess
Discussion:
-10% of AIDS pts., up to 40% of CNS infections
in AIDS
-up to 70% seropositivity in general population
-clinical: H/A, fever, lethargy, focal neurologic
deficit
-necrotizing encephalitis with thin walled abscess
formation
-1-4 cm lesions, small lesions solid enhancement,
larger ring enhancing
-locations: BG, WM, CM jcn
-major ddx in AIDS= lymphoma
-helpful distinguishing
factors: no spread across corpus callosum, larger number of small lesions,
response to Abx