Lymphoma

Findings:
Axial contrast enhanced CT of the orbits demonstrates an enhancing left preseptal mass, adjacent to the lacrimal gland.

Differential Diagnosis:
The imaging characteristics are not specific, which allows for a broad differential including lymphoma, primary salivary gland tumors, EG, melanoma, and metastasis.

Discussion:
Lymphoma may be intra- or extraconal. The lesions usually enhance strongly but may have some slight hypointensity on T2 due to hypercellularity. The tumors usually mold to the globe margin and may appear nonaggressive, or may be diffusely infiltrative simulating pseudotumor. Since lymphoma and pseudotumor often have similar imaging characteristics, history may be helpful to distinguish the two in some cases.  NHL is by far the most common. <1% of cases have the orbit as the primary or only site. Bone destruction is uncommon.

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