Open Lipped Schizencephaly
Findings:
A large CSF intensity cleft extends from the left lateral
ventricle to the frontal cortex, lined by gray matter. Sulcation is abnormal
on the right, with thickened cortex and pachygyria.
Differential Diagnosis:
schizencephaly versus porencephaly. Lining by gray matter
distinguishes between the two.
Discussion:
-schizencephaly is the most common migrational
anomaly occurring at approximately 6 weeks gestation.
-other migrational anomalies: lissencephaly, polymicrogyria,
pachygyria
-infarct vs. developmental, TORCH
-50% have septo-optic dysplasia
-80% rule- bilateral, open, symmetric